“This is where reliable therapeutic approaches are still lacking in the reality of colorectal cancer patients. Dominic Denk, physician at Frankfurt University Hospital, in Germany, and first author of the current study. “Our findings are particularly exciting because the focus is not on the tumor cell but on the immune system, the natural defense against cancer,” said Dr. They found that UA induced “strongly protective” anti-tumor T cell immunity in mice both when consumed in food and when used alongside CAR-T cell therapy, a treatment in which T cells - a type of immune cell - are altered to attack cancer cells. Recently, researchers explored the effects of UA on colorectal cancer in mice. Other studies have found that UA has immunomodulatory effects in cells that reduce inflammation alongside cells that enhance immune function.įurther study of the effects of UA on immune function could lead to the development of anti-tumor treatments. In turn, this encourages the creation of new mitochondria and slows the progression of age-related diseases. Recent studies show that concentrated forms of urolithin A (UA), a natural product of pomegranate digestion, induce mitophagy - the breakdown of old or redundant “cellular powerhouses” known as mitochondria. A patient’s chances of survival can be predicted by their immunoscore, which is calculated from the density of cell-death-inducing cells (CD8+ cells) inside tumors. The researchers noted that further research is needed to better understand the underlying mechanisms and see if the findings can be replicated in humans.Ĭolorectal cancer is the third most commonly diagnosed cancer globally.They found that, in mouse models, the metabolite limits tumor growth and acts synergistically with immunotherapy.Urolithin A is the result of gut bacteria metabolizing a type of polyphenol found in pomegranates.Researchers investigated the effects of a metabolite called urolithin A on colorectal cancer.Share on Pinterest A byproduct of pomegranate digestion may help fight colorectal cancer, a mouse study suggests.
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